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RUCONEST®
Safety

Clinical trials

RUCONEST® is well tolerated in patients with acute HAE attacks1-6

Adverse reactions occurring in ≥2% of patients treated for an acute attack in 7 studies¹

System organ class

Adverse reaction

Frequency

Nervous system disorders

Headache

Uncommon

Vertigo

Uncommon

Hypoesthesia

Uncommon

Dizziness

Uncommon

Ear and labyrinth disorders

Auricular swelling

Uncommon

Respiratory, thoracic and mediastinal disorders

Throat irritation

Uncommon

Gastrointestinal disorders

Nausea

Common

Diarrhoea

Uncommon

Abdominal discomfort

Uncommon

Oral paraesthesia

Uncommon

Skin and subcutaneous tissue disorders

Urticaria

Uncommon

For a complete list of side effects, please refer to the RUCONEST® Summary of Product Characteristics.

Real world

What about real world evidence for safety?

Real world evidence from a European registry of 2,356 attacks over 8 years demonstrated that RUCONEST® is well tolerated.6

NO
hypersensitivity events were reported6

NO
thromboembolic events were reported6

NO
treatment related serious adverse events occurred6

References
1. RUCONEST®. SmPC. Jun 2021.
2. Zuraw B, et al. J Allergy Clin Immunol 2010 Oct;126(4):821-827.
3. Moldovan D, et al. Clin Exp Allergy 2012 Jun;42(6):929-935.
4. Riedl M, et al. Ann Allergy Asthma Immunol 2013;112(2):163-169.
5. Li H, et al. J Allergy Clin Immunol Pract 2015;3(3):417-423.
6. Valerieva A, et al. World Allergy Organ J 2021;14(4):100535.