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RUCONEST®
Patient Response

RUCONEST® in children with HAE has shown a comparable safety and efficacy profile to adults1,2*

RUCONEST® is indicated for treatment of acute HAE attacks in children ≥2 years with HAE due to C1-INH deficiency2**

95.9% (70/73, N=20) of attacks in children aged 5-14 years were treated with a single dose of RUCONEST®1

Median time to onset of symptom relief was 60 minutes1

No treatment-related SAEs or hypersensitivity reactions were reported1

Incidence of AEs in patients treated for >1 attack did not increase1

*RUCONEST® has an established safety profile in children with HAE >5 years of age.
**RUCONEST® is licensed for children 2 years and above with limited data available for children aged between 2-5 years.²
AE: adverse event; HAE: hereditary angioedema; SAE: serious adverse event; SmPC: Summary of Product Characteristics.

RUCONEST® remains effective regardless of BMI3

  • Patients with a high BMI (≥30 kg/m2) tend to experience a higher frequency of attacks3
  • For patients with a BMI ≥30 kg/m2, some acute HAE treatments may be less effective4
  • RUCONEST® remains effective in patients weighing ≥180 kg3

Emergency setting use

Why is RUCONEST® well suited for use in the emergency setting?

Fast, effective, sustained relief in one dose regardless of attack location or severity5-7

A RUCONEST® vial has a shelf life of 4 years, at room temperature, making it convenient for storing at the hospital2

Established safety profile for adults and children ≥5 years1,2

C1 esterase inhibitor (C1-INH) returned to normal levels* in 94% of patients, regardless of age or weight, with just one dose**3

*The normal range of plasma C1-INH in healthy individuals is between 0.70–1.30 U/mL.⁸
**Dosing of RUCONEST® is weight dependent and one dose is, therefore, based on patient weight as follows; <84 kg: 50 U/kg (1–2 vials); ≥84 kg: fixed dose of 2 vials (4200 U).²

RUCONEST®: fast, effective, sustained relief, in one dose4-8

RECOMBINANT

Identical amino acid sequence to native human C1-INH9

FAST

Rapid onset of action6,7

EFFECTIVE

96% of patients experience relief with just one dose5,8

SUSTAINED RELIEF

One dose stops attacks for at least 3 days in 93% of patients4

RUCONEST® is indicated for treatment of acute angioedema attacks in adults, adolescents, and children (aged 2 years and above) with hereditary angioedema (HAE) due to C1 esterase inhibitor deficiency.

References

  1. Reshef A, et al. Pediatr Allergy Immunol. 2019;30(5):562-568.
  2. RUCONEST® SmPC. Jun 2021.
  3. Farrell C, et al. Br J Clin Pharmacol. 2013;76(6):897-907.
  4. Bernstein JA, et al. Clinical Therapeutics. 2014;36(4):518-525.
  5. Li H, et al. J Allergy Clin Immunol Pract. 2015;3(3):417-423.
  6. Riedl M, et al. Ann Allergy Asthma Immunol. 2013;110(4):295-299.
  7. Riedl M, et al. Ann Allergy Asthma Immunol. 2014;112(2):163-169.
  8. Van Veen H, et al. J Biotechnol 2012;162(2-3):319-326.
  9. Riedl M. Clin Drug Investig 2015;35(7):407-417.