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Profiles

Who are suitable patients for RUCONEST®?

Treatment goals

Most patients would like a cure for their HAE and a life free from attacks.2

However, until a cure is found, patients would like to be empowered to stop attacks when they happen.2

Treatment goals for patients with HAE include a treatment that:2

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More effectively manages their HAE so they can live with more confidence

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Is convenient and effective

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Does not disrupt their daily life and activities

Patient profiles

Meet our patients. How could treatment with RUCONEST® benefit them?

Liam

Aged 44

Brief background

  • Diagnosed at 18 years
  • Mother and sister have HAE
  • Divorced and currently lives alone

Work and lifestyle

  • Inspector on London rail network
  • Anxious about having an HAE attack at work, although his colleagues are supportive


Goals

  • Wants to progress in his job, but is anxious about getting an attack so worries about asking for more responsibility at work
  • Wants to be able to manage breakthrough attacks with a treatment that works quickly with one dose

Clinical profile

  • Danazol 200mg/day for several years
  • Switched to icatibant 30 mg when he was 32
  • Attacks increased in frequency, switched to C1 IV prophylaxis, still experiencing 2-3 attacks per month (means he is IV trained)
  • Now on prophylaxis with lanadelumab 300 mg every 3 weeks
  • Has experienced breakthrough attack every 4-5 months, uses icatibant to treat these, but symptoms are not always resolved
  • Has suffered 3-4 laryngeal attacks per year and is very anxious about having further severe attacks

Personal information

  • Liam wants to get over his anxiety about having an HAE attack which is restricting his lifestyle

Not a real patient. For illustrative purposes only.

Joachim

Aged 26

Brief background

  • First attack aged 17 just before starting university course
  • Father and uncle both have HAE

Work and lifestyle

  • Post-graduate student in engineering
  • Lives with fiancé
  • Volunteer with youth group, keen gamer and wants to travel


Goals

  • Wants to go on holiday and to continue volunteering without the worry of attacks

Clinical profile

  • On demand treatment with icatibant at a dose of 30 mg subcutaneously
  • He has had 4 attacks in the last 3 months
  • First was dealt with quickly with one dose, but for the others he needed 2 injections and ended up going to A&E twice, including for a laryngeal attack

Personal information

  • Fiancé is supportive and helps with treatment
  • Joachim wants to lead a normal life, and to have confidence that his treatment will manage his attacks in a single

Not a real patient. For illustrative purposes only.

Sylvie

Aged 50

Brief background

  • Diagnosed at 15 years
  • Married with two children, one has HAE

Work and lifestyle

  • Works as a primary school teacher


Goals

  • Leads a busy life and is looking for stability with a treatment that works first time
  • Doesn’t want the children at school and people around her to be affected by her attacks
  • Ambitious to continue to progress in her career without HAE holding her back

Clinical profile

  • Treated with on-demand Cinryze® 1000 IU plasma-derived C1-inhibitor for acute attacks
  • She finds that there are quite a number of times that she needs to redose which is inconvenient

Personal information

  • Husband is supportive and will help administer treatment for her and their son
  • Sylvie wants stability and to be able to manage her breakthrough attacks effectively, without disrupting her life
  • She wants her son to be able to manage his attacks effectively and not to let HAE negatively affect his life

Not a real patient. For illustrative purposes only.

References

  1. RUCONEST® SmPC. Jun 2021.
  2. Validated at a series on interviews with HAE physicians from the UK, the Netherlands, Italy, Spain, France, Czech Republic, and Poland.