Patient
Profiles

Goals

• Wants to progress in his job, but is anxious about getting an attack so worries about asking for more responsibility at work
• Wants to be able to manage breakthrough attacks with a treatment that works quickly with one dose

Clinical profile

• Danazol 200mg/day for several years
• Switched to icatibant 30 mg when he was 32
• Attacks increased in frequency, switched to C1 IV prophylaxis, still experiencing 2-3 attacks per month (means he is IV trained)
• Now on prophylaxis with lanadelumab 300 mg every 3 weeks
• Has experienced breakthrough attack every 4-5 months, uses icatibant to treat these, but symptoms are not always resolved
• Has suffered 3-4 laryngeal attacks per year and is very anxious about having further severe attacks

Personal information

• Liam wants to get over his anxiety about having an HAE attack which is restricting his lifestyle

Goals

• Wants to go on holiday and to continue volunteering without the worry of attacks

Clinical profile

• On demand treatment with icatibant at a dose of 30 mg subcutaneously
• He has had 4 attacks in the last 3 months
• First was dealt with quickly with one dose, but for the others he needed 2 injections and ended up going to A&E twice, including for a laryngeal attack

Personal information

• Fiancé is supportive and helps with treatment
• Joachim wants to lead a normal life, and to have confidence that his treatment will manage his attacks in a single

Goals

• Leads a busy life and is looking for stability with a treatment that works first time
• Doesn’t want the children at school and people around her to be affected by her attacks
• Ambitious to continue to progress in her career without HAE holding her back

Clinical profile

• Treated with on-demand Cinryze^® 1000 IU plasma-derived C1-inhibitor for acute attacks
• She finds that there are quite a number of times that she needs to redose which is inconvenient

Personal information

• Husband is supportive and will help administer treatment for her and their son
• Sylvie wants stability and to be able to manage her breakthrough attacks effectively, without disrupting her life
• She wants her son to be able to manage his attacks effectively and not to let HAE negatively affect his life